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A clipper ship heads into a violent storm. Cholera has wiped out everyone on board except two passengers: William a former nobleman determined to recover his manor, and his wife Elizabeth, resolved to save her aunt’s failed coffee farm. They fight for their lives before the vessel crashes on a Bahian shore. On a deserted beach, the refugees become separated. William tracks his missing wife, but discovers murder at a sugar plantation. Accused of killing the owner, he is held hostage by a notorious landlord, Alfonso and learns that his wife may be on her way to Rio de Janeiro to participate in a dangerous blood transfusion, sixty years before blood typing. The experiment purports to save eight-year old future leader, Dom Pedro II who also has contracted cholera. William arrives in Rio. At a peasant rally, he encounters Emile Rojas, a radical speaking out against the land barons and learns the blood test is really an attempt to assassinate young ruler. He is too late to stop the test, but finds a vial of blood with immunity properties against cholera. He holds health, wealth or happiness in a tiny jar of red. He could save his own life, receive one million reis from the Brazilian government to revive its future leader or rescue his wife from conspirators in exchange for the vessel, but there’s only enough blood for one choice.